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Spinal cord stimulation

Clinical evidence

Robust clinical evidence on spinal cord stimulation (SCS)

We are committed to advancing SCS through high-quality robust clinical research on SCS indications using multiple stimulation waveforms, including low-dose, high-dose, tonic, and Differential Target Multiplexed™ spinal cord stimulation (DTM™ SCS).

Lower Limb

86%

of patients with diabetic peripheral neuropathy pain in the lower limbs reported treatment success after receiving SCS therapy for one year.^†,1

Upper limb pain

100%

of subjects with upper-limb were satisfied or very satisfied with DTM™ SCS at 12 months.²

Upper limb study

Back pain

2 RCTs

Medtronic conducted 2 randomized control trials (RCTs) that evaluated DTM™ SCS versus conventional stimulation.^3,4

NOVA RCT study
DTM™ RCT manuscript

Evidence supporting SCS

Access recent, robust pre-clinical and clinical research.

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† Success rates in a population of patients treated with SCS in two studies and followed for five years.

van Beek M, Geurts JW, Slangen R, et al. Severity of neuropathy is associated with long-term spinal cord stimulation outcomes in painful diabetic peripheral neuropathy: Five-year follow-up of a prospective two-center clinical trial. Diabetes Care. 2018;41(1):32–38. doi:10.2337/dc17-0983.
White T, Justiz R, Fishman M, et al. Differential Target Multiplexed Spinal Cord Stimulation for the Treatment of Chronic Intractable Upper Limb Pain: 12-Month Results From a Prospective, Multicenter Study. Neuromodulation. 2024 Jul 24:S1094-7159(24)00628-7.
Fishman M, Cordner H, Justiz R, et al. Twelve-month results from multicenter, open-label, randomized controlled clinical trial comparing differential target multiplexed spinal cord stimulation and traditional spinal cord stimulation in subjects with chronic intractable back pain and leg pain. Pain Pract. 2021;21(8):912–923. doi: 10.1111/papr.13066.
White T, Justiz R, Almonte W, et al. 12-Month Results from a Randomized Controlled Trial Comparing Differential Target Multiplexed Spinal Cord Stimulation and Conventional Spinal Cord Stimulation in Subjects with Chronic Refractory Axial Low Back Pain not Eligible for Spine Surgery. 2024. North American Spine Society Journal (NASSJ), doi: https://doi.org/10.1016/j.xnsj.2024.100528

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