Therapies and procedures
Symplicity™ blood pressure procedure
Lifestyle changes and medications have defined hypertension care — until now. See how the Symplicity™ blood pressure procedure complements existing hypertension treatment protocols, review clinical evidence, and sign up to receive resources directly through email.
This is the turning point in hypertension care.
Current hypertension care strategies are not always enough to help patients achieve blood pressure control. The Symplicity Spyral™ renal denervation (RDN) system is used during the Symplicity™ procedure — the first interventional approach using a single catheter and radiofrequency (RF) energy that complements medications and lifestyle modifications to help reduce blood pressure.
Watch a short video to see why we’ve spent the last 10 years dedicated to developing an alternative solution to manage this disease.
Read on to preview:
Evidence showing safety and efficacy
The Symplicity Spyral™ RDN system is proven to achieve significant, safe, and sustained blood pressure reductions in the presence and absence of medications in multiple clinical trials and a real-world patient registry.1–4
Results mary vary.
How the system works
The Symplicity Spyral™ system is comprised of the Symplicity Spyral™ multi-electrode renal denervation catheter and the Symplicity G3™ renal denervation RF generator.
Patients whose blood pressure is difficult to control may have an overactive sympathetic nervous system. The Symplicity™ procedure aims to suppress this inappropriately elevated sympathetic drive. The Symplicity Spyral™ system offers a versatile, simple, and minimally invasive method to perform renal denervation.‡,5
The procedure is performed by interventionalists due to its similarity to other procedures they perform every day.
Patient selection considerations
Understanding which patients could benefit from the Symplicity™ procedure is an important step when considering this therapy.
Your patients may benefit if they:
Have uncontrolled hypertension
Consider patients where lifestyle modifications and antihypertensive medications haven’t adequately controlled blood pressure.
Are willing to undergo an interventional procedure
Consider patients who opt for the Symplicity™ procedure following shared decision-making and an attempt at lifestyle modifications and medical therapy.
Learn more and access resources.
Get a better understanding of what your patients can expect following the procedure and access resources you can use to help explain it to them.
Renal denervation shows promise as an adjunctive therapy.
The 2023 SCAI position statement recognizes renal denervation as a promising therapy for treating hypertension. Read the full statement to review recommendations for success, including patient selection, operator competency, procedural training and techniques, and organizational recommendations.
We‘re here for you at every turn.
Our goal is to support you and your practice as you become familiar with this therapy. We‘ve thought through everything you‘ll need to activate, advance, accelerate, and optimize a Symplicity™ renal denervation program and successfully incorporate the procedure into your practice.
Our unwavering, long-term dedication to renal denervation has resulted in extensive clinical evidence, in-depth training and education, detailed resources to support patient care pathway development and referrals, and more. Download our brochure to learn more about how we can support you on this journey.
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View patient selection criteria.
Learn how to identify the appropriate patients for the Symplicity™ procedure.
Establish a Symplicity™ RDN program.
See our suggested framework to help create a care pathway.
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† Includes Symplicity Spyral™ and Flex RDN catheters.
‡ One catheter size treats vessels 3-8 mm.
- Böhm M, Kario K, Kandzari DE, et al. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. Lancet. 2020;395(10234):1444–1451. doi: 10.1016/S0140-6736(20)30554-7.
- Kandzari D, Townsend R, Kario K, et al. Safety and efficacy of renal denervation in patients taking antihypertensive medication. J Am Coll Cardiol. 2023;82(19):1809–1823. doi: 10.1016/j.jacc.2023.08.045.
- Mahfoud F, Kandzari DE, Kario K, et al. Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial. Lancet. 2022;399(10234):1401–1410. doi: 10.1016/S0140-6736(22)00455-X.
- Mahfound F, Mancia G, Schmieder R, et al. Outcomes following radiofrequency renal denervation according to antihypertensive medications: subgroup analysis of the Global SYMPLICITY Registry DEFINE. EuroPCR 2023.
- Medtronic Symplicity Spyral™ multi-electrode renal denervation catheter instructions for use.