Clinical Evidence

Clinical evidence

The Medtronic CoreValve™/Evolut™ platform is supported by a robust body of clinical evidence. Explore the CoreValve™/Evolut™ clinical success.

Comprehensive clinical evidence

Stay up to date on the latest clinical evidence from Medtronic. Key summaries demonstrate the efficacy of the CoreValve™/Evolut™ TAVR platform.

Explore evidence summaries

This image shows an interventional cardiologist dressed in a blue gown and protective wear in a hybrid operating room performing a transcatheter aortic valve (TAV) procedure.

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SMART Trial

Medtronic invested in the first-ever randomized, head-to-head trial comparing Evolut™ TAVR and SAPIEN™* TAVR systems in patients with small aortic annuli. This patient population is predominately women, who are often underrepresented and understudied in clinical trials.

See the results

Real-world results

The CoreValve™/Evolut™ platform provides reproducible results from clinical trial to the real world.

Explore our STS/ACC TVT Registry™* data that supports the excellent clinical performance seen in our trials.

Discover the data

This is an image of Julia, a Medtronic transcatheter aortic valve replacement or implantation patient, depending on region or country, smiling.

This is an image of a male healthcare professional standing and listening to the heart of an older female patient who is sitting down.

EXPAND TAVR II Pivotal Trial

The purpose of the EXPAND TAVR II Pivotal Trial is to explore the treatment of moderate aortic stenosis (AS) with early aortic valve replacement (AVR) before AS becomes severe. This can lead to preservation of cardiac function, prevention of further deterioration in cardiac function, and prevention of death in some patients.

View EXPAND TAVR II Trial