Why sac regression?

  • Sac regression is defined by the Society for Vascular Surgery (SVS) as the reduction in maximum diameter of the aneurysm sac by ≥ 5 mm.6
  • Latest data suggests aneurysm sac regression is associated with better long-term outcomes.7

Addressing sac regression factors with Endurant™ stent graft

Endurant™ AAA stent graft has demonstrated low type I and type II endoleaks in broad patient anatomies,5 with:

  • Accurate placement and controlled deployment2
  • Continuous seal, fixation, and graft conformability3
  • Durable hemostatic barrier and resistance against type II endoleaks4

Endurant™ II-IIs is designed to provide continuous seal in a dynamic environment†,3

Methodology
Radial force was tested and micro-CT scans were evaluated by an independent lab to model the Endurant™ stent graft performance in the proximal seal zone through the cardiac cycle.

Results
M-stent maintains even distribution of contact pressure, resulting in conformability in a pulsatile environment.3

See the Endurant™ II-IIs system perform in a dynamic environment.†

Normalized contact pressure in systole (120 mmHg)†

This is an Endurant II/IIs stent graft heat map showing even distribution of contact pressure in the proximal seal.

EVAR success

Aneurysm sac regression is a key indicator6 for EVAR success.

Dr. Ross Milner, MD, Professor of Surgery, Co-director, Center for Aortic Diseases at the University of Chicago, discusses his thoughts on aneurysm sac regression post-EVAR.

A new paradigm shift

Hear physicians’ thoughts on aneurysm sac regression post-EVAR ― watch the on-demand webcast.

  • Moderated by Prof. Jean-Pierre Becquemin, MD
  • Panel includes Prof. Hence Verhagen, MD, PhD; Prof. Michel Reijnen, MD, PhD; and Dr. Apostolos Tassiopoulos, MD

“If you have sac shrinkage in the first year, the need for secondary interventions and therefore the need for intensive follow-up is different than those that don’t shrink.”

–Prof. Hence Verhagen, MD, PhD

Watch full webcast on Academy (open in new window)

Clinical evidence VQI data

Latest data suggests aneurysm sac regression is associated with better long-term outcomes.7

Cohort that demonstrated sac regression at one year had significantly better outcomes than stable and expanding sac cohorts.

This Kaplan-Meier curve illustrates the latest clinical data, which suggests aneurysm sac regression is associated with better long-term outcomes.

Endurant™ stent graft sac regression data associated with better long-term outcomes

ENGAGE OUS Registry confirms sac regression link to better long-term outcomes. Patients with regressing sacs at one year had statistically significant better freedom from (FF) all-cause mortality (ACM) and FF secondary endovascular reinterventions than patients with stable or expanding sacs.8

Freedom from all-cause mortality

This chart of the ENGAGE OUS 5-year data confirms aneurysm sac regression is associated with better long-term outcomes.

Freedom from secondary endovascular reinterventions

This ENGAGE OUS 5-year data chart shows patients with regressing aneurysm sacs post-EVAR had statistically better outcomes than patients with stable and expanding aneurysm sacs.

The Endurant AAA stent graft is the standard of EVAR durability.9

See the 10-year data

Endurant™ data shows consistent high sac regression rates

Endurant™ demonstrates consistent and high sac regression rates across straightforward and complex anatomies.

10-year sac regression rates‡

View a 10-year chart on sac regression.

1-year sac regression is indicative of 5-year sac dynamics

Of those with sac regression at one year8:

  • 86% of patients with images at five years continue to have sac regression.
  • 2% have sac increase at five years.

Sac dynamics at follow-up time points8

This expanded bar chart shows the ENGAGE OUS five-year data, which suggests patients with aneurysm sac regression at one year continue to have aneurysm sac regression at five years.

Challenging EVAR procedure video case study

Dr. Ross Milner, MD, reviews the case of a challenging EVAR patient that resulted in a regressing aneurysm sac.

Case study of aneurysm sac regression with the Endurant™ II-IIs AAA stent graft

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