Description
Simple, safe, and effective intrathecal therapy
Unlike systemic medications that must be absorbed systemically and must cross the blood-brain barrier to reach the receptors on the spinal cord to be effective, an implanted SynchroMed™ III implantable pump and catheter deliver prescribed amounts of medication directly into the cerebrospinal fluid in the intrathecal space bypassing the blood-brain barrier.
Targeted drug delivery (TDD) into the intrathecal space offers effective relief at a fraction of the systemic dose, which can reduce side effects.1–4
- Hamza, M et al. Prospective Study of 3-Year Follow-Up of Low-Dose Intrathecal Opioids in the Management of Chronic Nonmalignant Pain. Pain Medicine. (United States) 13, 1304–1313 (2012).
- Smith, TJ et al. Randomized clinical trial of an implantable drug delivery system compared with comprehensive medical management for refractory cancer pain: Impact on pain, drug-related toxicity, and survival. Journal of Clinical Oncology. 20, 4040–4049 (2002).
- Rushton, DN. Upper Motor Neurone Syndrome and Spasticity: Chapter 10 Intrathecal Baclofen for the Control of Spinal and Supraspinal Spasticity. ed. Barnes, MP and Johnson, GR pages 181–192. (Cambridge University Press, 2008). doi:10.1017/cbo9780511544866.011.
- Deer, T et al. Intrathecal drug delivery for treatment of chronic low back pain: Report from the National Outcomes Registry for Low Back Pain. Pain Medicine. 5, 6–13 (2004).
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