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Patient Stories & Clinical Evidence

  

SYMPLICITY™ BLOOD PRESSURE PROCEDURE

Clinical evidence and patient stories

Proven to help reduce blood pressure,1,2 the Symplicity™ procedure complements typical high blood pressure treatments like lifestyle changes and medications.

Alert Important Safety Information

  

Illustration of a doctor standing in front of a man and a woman

  

Clinical evidence

The Symplicity™ blood pressure procedure can help get your numbers moving in the right direction.1,2

Two clinical studies monitored people who were either on or off medications after receiving the procedure†,1–3:

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65% experienced a greater than or equal to 5 mmHg reduction.

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50% experienced a greater than or equal to 10 mmHg reduction.

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35% experienced a greater than or equal to 15 mmHg reduction.

† Studies focused on 388 people on and off medications. Results for people on medication were captured at six months and people off medication were captured at three months.

Patient stories

More than 30,000 people worldwide have received this procedure.4 Listen to some of their stories to learn more.

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Paul’s story

Paul talks about how the Symplicity™ blood pressure procedure made a difference in his life.

Danny’s story

Not every person will experience the same results. The Symplicity™ blood pressure procedure does have known risks. These risks should be considered in relation to the potential benefits of the procedure.

Find a Symplicity™ specialist.

Here’s how you can find a doctor near you who is experienced in the Symplicity™ blood pressure procedure.

Find a Symplicity™ specialist

Is the Symplicity™ blood pressure procedure right for you?

Answer a few simple questions, and then talk to your doctor to see if the procedure may be right for you.

Answer a few questions

1. Kandzari DE, Townsend RR, Kario K, et al. Safety and efficacy of renal denervation in patients taking antihypertensive medications. J Am Coll Cardiol. 2023;82(19):1809–1823. doi: 10.1016/j.jacc.2023.08.045.

2. Böhm M, Kario K, Kandzari DE, et al. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. Lancet. 2020;395(10234):1444–1451. doi: 10.1016/S0140-6736(20)30554-7.

3. Symplicity Spyral™ renal denervation system. FDA presentation. U.S. FDA Circulatory Systems Devices Panel. Meeting date: August 23, 2023.

4. RDN catheter historical data. Data include both Symplicity™ Flex and Symplicity Spyral™. February 2025. Medtronic data on file.

5. FDA. High blood pressure(opens new window). Published February 2021. Accessed October 16, 2024.

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