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How It Works

  

SYMPLICITY™ BLOOD PRESSURE PROCEDURE

How it works

The Symplicity™ blood pressure procedure is a different kind of treatment that complements lifestyle changes and medications to help control your blood pressure.1

Alert Important Safety Information

  

Illustration of a patient receiving blood pressure check with readings of systolic and diastolic blood pressure shown

  

What the Symplicity™ procedure does

The Symplicity™ blood pressure procedure calms excessively active nerves near the kidneys that may be contributing to your high blood pressure.2

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Expect a safe and effective procedure.

  • The Symplicity™ procedure is proven to be safe and effective to help reduce high blood pressure.3,4
  • Clinical trial results show no impact to kidney function.†,5
  • More than 30,000 people worldwide have received it.6

Not every person will experience the same results. The Symplicity™ blood pressure procedure does have known risks. These risks should be considered in relation to the potential benefits of the procedure.

One procedure to help lower your blood pressure

The Symplicity™ blood pressure procedure is done in a hospital and usually takes about an hour. Some people go home the same day. Others stay overnight. You doctor will decide what is right for you.

What to expect

Find a Symplicity™ specialist.

Here’s how you can find a doctor near you who is experienced in the Symplicity™ blood pressure procedure.

Find a Symplicity™ specialist

Is the Symplicity™ blood pressure procedure right for you?

Answer a few simple questions, and then talk to your doctor to see if the procedure may be right for you.

Answer a few questions

† Clinical trial results on participants three years after receiving this procedure showed no negative effects on their kidney function.

1. Medtronic Symplicity Spyral™ multi-electrode renal denervation catheter instructions for use. Medtronic; 2023.

2. Coates P, Tunev S, Trudel J, Hettrick DA. Time, temperature, power, and impedance considerations for radiofrequency catheter renal denervation. Cardiovasc Revasc Med. 2022;42:171–177. doi: 10.1016/j.carrev.2022.02.018.

3. Kandzari DE, Townsend RR, Kario K, et al. Safety and efficacy of renal denervation in patients taking antihypertensive medications. J Am Coll Cardiol. 2023;82(19):1809–1823. doi: 10.1016/j.jacc.2023.08.045.

4. Böhm M, Kario K, Kandzari DE, et al. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. Lancet. 2020;395(10234):1444–1451. doi: 10.1016/S0140-6736(20)30554-7.

5. Schlaich M, Mahfoud F, Williams B, et al. Long-term safety and efficacy of renal denervation with the Symplicity Spyral catheter in the Global SYMPLICITY Registry. Oral presentation at: American Society of Nephrology Kidney Week; November 2021; San Diego, CA.

6. RDN catheter historical data. Data include both Symplicity™ Flex and Symplicity Spyral™. February 2025. Medtronic data on file.

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