CRT-Ps
Serena™ CRT-P MRI SureScan™
CRT-Ps
Serena™ CRT-P MRI SureScan™
The Serena™ CRT-P MRI SureScan™ is enabled with BlueSync™ technology, allowing for tablet-based programming and app-based remote monitoring.
Description
Serena™ CRT-Ps are enabled with BlueSync™ technology, allowing for tablet-based programming and app-based remote monitoring. These devices include an exclusive algorithm to manage atrial fibrillation (AF).
Unmatched feature suite
PhysioCurve design for patient comfort
Tapered at the head and bottom of device to reduce skin pressure and promote patient comfort
Designed with lead wrap in mind — landing area to minimize additional stresses on the lead1
Exclusive algorithms to optimize cardiac resynchronization (CRT) delivery
Exclusive algorithms to manage AF and optimize CRT delivery
- Reactive ATP™ algorithm opportunistically attempts to terminate an AF episode when the rhythm organizes and/or slows.
- 36% relative reduction in AT/AF episodes ≥ 7 days with Reactive ATP™ Algorithm∆1
- AdaptivCRT™ Algorithm adapts to patients’ changing needs by optimizing CRT pacing minute-to-minute.
- 16% mortality in AdaptResponse at 5 years is the lowest of any radomized CRT trial, when accounting for NYHA class.2–9
- 93% response rate overall at 6 months, highest of any CRT trial1,10–17
- High percent Adaptive LV pacing associated with 24% significant reduction in mortality/HF events2
- 41% lower rate of device change-outs for battery depletion through 8 years with AdaptivCRT™ algorithm2
Reimagined connectivity with BlueSync™ technology
Serena™ CRT-Ps with BlueSync™ technology enables secure, wireless communication.
Streamlined heart failure management with CareAlert™ notifications
Time to a clinical decision was about seven times faster with the use of Medtronic CareAlert™ notifications compared to standard office follow-up.7
Clinical management alerts:
- Atrial tachyarrhythmia / atrial fibrillation (AT/AF) daily burden enable
- Average ventricular rate during AT/AF
- Monitored ventricular tachyarrhythmia (VT) episode
- Ventricular pacing < 90%
Device management alerts:
- Low battery voltage recommended replacement time (RRT)
- Atrial pacing enable
- Right-ventricular (RV) pacing enable
- Left-ventricular (LV) pacing enable
- Atrial capture enable
- RV capture enable
- LV capture enable
System features and exclusive algorithms
Quad models:
- BlueSync™ technology
- AdaptivCRT™ algorithm
- Multiple point pacing
- OptiVol™ 2.0 fluid status monitoring
- MRI SureScan™ technology
- PhysioCurve design
- Attain™ Performa™ advanced quadripolar lead and VectorExpress™ LV automated test
Non-quad models:
- BlueSync™ technology
- AdaptivCRT™ algorithm
- OptiVol™ 2.0 fluid status monitoring
- MRI SureScan™ technology
- PhysioCurve design
Ordering information
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The Bluetooth™ word mark and logos are registered trademarks owned by Bluetooth SIG, Inc. and any use of such marks by Medtronic is under license.
† Comparing AdaptivCRT™ to echo-optimized BiV pacing in patients with normal AV conduction, percentage of patients improved in Packer clinical composite score (CCS) at 6-month follow-up. CCS is a composite measure of mortality, HF hospitalizations, and symptomatic changes.
‡ Patients who received AdaptivCRT™ were associated with a 29% relative reduction in all-cause mortality versus conventional CRT (after adjusting for other potential risk factors including age, gender, LVEF, NYHA class, QRS duration, AF, CAD, hypertension, AV block, and LBBB).
§ Most of the reduction in AF occurred in subgroups with prolonged AV conduction at baseline and with significant left atrial reverse remodeling.
◊ Compared to matched control group.
- Crossley GH, Padeletti L, Zweibel S, Hudnall JH, Zhang Y, Boriani G. Reactive atrial-based antitachycardia pacing therapy reduces atrial tachyarrhythmias. Pacing Clin Electrophysiol. July 2019;42(7):970–979.
- Wilkoff BL,Filippatos, G, Leclercq C, Gold MR, Hersi AS, Kusano K, et al. Adaptive versus conventional cardiac resynchronization therapy in patients with heart failure (AdaptResponse): A global, prospective, randomised controlled trial. Lancet. 2023;402(10408):1147–57.
- Abraham WT, Fisher WG, Smith AL, Delurgio DB, Leon AR, Loh E, et al. Cardiac resynchronization in chronic heart failure. N Engl J Med. 2002;346(24):1845–53.
- Young JB, Abraham WT, Smith AL, Leon AR, Lieberman R, WIlkoff B, et al. Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure: the MIRACLE ICD Trial. JAMA. 2003;289(20):2685–94.
- Bristow MR, Saxon LA, Boehmer J, Krueger S, Kass DA, DeMarco T, et al. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med. 2004;350(21):2140–50.
- Cleland JGF, Daubert JC, Erdmann E, Freemantle N, Gras D, Kappenberger L, et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med. 2005;352(15):1539–49.
- Linde C, Abraham WT, Gold MR, St. John Sutton M, Ghio S, Daubert C. Randomized trial of cardiac resynchronization in mildly symptomatic heart failure patients and in asymptomatic patients with left ventricular dysfunction and prevoius heart failure symptoms. J Am Coll Cardiol. 2008;52(23):1834–43.
- Moss AJ, Hall WJ, Cannom DS, et al. Cardiac-resynchronization thereapy for the prevention of heart-failure events. N Engl J Med. 2009;361:1329–38.
- Tang ASL, Wells GA, Talajic M, Arnold MO, Sheldon R, Connolly S, et al. Cardiac-resynchronization therapy for mild-to-moderate heart failure. N Engl J Med. 2010;363(25):2385–95.
- Forleo GF, Santini L, Giammaria M, Potenza D, Curnis A, Calabrese V, et al. Multipoint pacing via a quadripolar left-ventricular lead: preliminary results from the Italian registry on multipoint left-ventricular pacing in cardiac resynchronization therapy (IRON-MPP) Europace. 2017;19(7):1170–77.
- Martin DO, Lemke B, Birnie D, Krum H, Lee KLF, Aonuma K, et al. Investigation of a novel algorithm for synchronized left-ventricular pacing and ambulatory optimization of cardiac resynchronization therapy: results of the adaptive CRT trial. Heart Rhythm. 2012;9(11):1807–14.
- Varma N, Auricchio A, Connolly AT, Boehmer J, Bahu M, Costanzo MR, et al. The cost of non-response to cardiac resynchromization therapy: characterizing heart failure events following cardiac resynchronizzation therapy. Europace. 2021;23(10):1586–95.
- Jackson KP, Faerestrand S, Philippon F, Yee R, Kong MH, Kloppe A, et al. Performance of a novel active fixation quadripolar left ventricular lead for cardiac resynchronization therapy: Attain Stability Quad clinical study results. J Cardiovasc Electrophysiol. 2020;31(5):1147–54.
- Abraham WT, León AR, St. John Sutton MG, Keteyian SJ, Fieberg AM, Chinchoy E, et al. Randomized controlled trial comparing simultaneous versus optimized sequential interventricular stimulation during cardiac resynchronization therapy. Am Heart J. 2012;164(5):735–41.
- Rickard J, Gold MR, Patel D, Wilkoff BL, Varma N, Sinha S, et al. Long-term outcomes in nonprogressors to cardiac resynchronization thereapy. Heart Rhythm. 2023;20(2):165–70.
- Chung ES, León AR, Tavazzi L, Sun JP, Nihoyannopoulos P, Merlino J, et al. Results of the Predictors of Response to CRT (PROSPECT) trial. Circulation. 2008;117(20):2608–16.
- Linde C, Abraham WT, Goldf MR, Daubert JC, Tang ASL, Young JB, et al. Predictors of short-term clinicial response to cardiac resynchronization therapy. Eur J Heart Fail. 2017;19(8):1056–63.