Brain channel monitoring

BIS™ Advance monitor

<p>The BIS™ Advance monitor empowers anesthesia providers by reflecting the anesthetic effect on a patient’s brain.</p>

Ordering information
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Features

More insights. For a more personalized anesthetic approach.3

  • Simple to read — large, high-resolution touchscreen monitor3
  • See the information you want — configurable data and settings3
  • Quickly review readings — color-coordinated data3
View the various features of the BIS™ Advance monitor from Medtronic.

Monitor details3

  1. EMG (electromyogram) shown in numerical and as a bar
  2. SQI (signal quality index)
  3. BIS™ value (with alarm range if programmed)
  4. SR (suppression ratio) percentage (with alarm limit if programmed)
  5. ST (suppression time) in minutes and seconds
  6. MF (median frequency)
  7. SEF (spectral edge frequency)
  8. Adjustable EEG amplitude scale and sweep speed
  9. Built-in troubleshooting guides
  10. Graphic display of BIS™ value and secondary variable
  11. High-resolution DSA (density spectral array)
  12. Two- or four-channel capabilities
See how BIS™ technology can help you improve the efficiency of your procedural workflow.

Designed for more efficient workflow

  • Save time with data output protocols that enable connectivity to electronic medical records (EMRs).3
  • Set system-wide default preferences to save time — no need to re-set every time.3
  • Maintain continuous monitoring when moving between care settings.

See the evidence for the BIS™ proven algorithm.

See a 38% icon.
Use up to 38% less anesthetic agents1,2,4–6 to help control cost.7,8
Patients monitored with BIS technology wake up 27-53% faster in the operating room.
Patients monitored with BIS™ technology wake up 27-53% faster in the OR.1,2,5,9
BIS technology 87% supports an increase in “excellent/fully oriented” status on PACU admission.
Patients monitored with BIS™ technology are 87% more fully awake and oriented upon arrival in the PACU and ready for discharger faster.1,2

Clinical evidence

Improved post anesthesia recovery

“The pooled data showed that the use of BIS was significantly associated with a lower incidence of POCD and improved recovery parameters (extubation time, time to eye opening, and time to discharge from the PACU).”

 

— Wei Zhuen Chew et al, Bispectral Index (BIS) Monitoring and Postoperative Delirium in Elderly Patients Undergoing Surgery: A Systematic Review and Meta-Analysis With Trial Sequential Analysis

Chew WZ, Teoh WY, Sivanesan N, San Loh P, Shariffuddin II, Ti LK, Ng KT. Bispectral index (BIS) monitoring and postoperative delirium in elderly patients undergoing surgery: A systematic review and meta-analysis With trial sequential analysis. Journal of Cardiothoracic and Vascular Anesthesia. 2022 Dec 1;36(12):4449–59.

Improved post anesthesia neurocognitive outcomes

“We found that BIS monitoring of the depth of anesthesia prevented POD, whereas EEG monitoring was not effective. BIS quantifies the depth of anesthesia based on EEGs, which enables a more accurate control of anesthetic concentration and increases patient safely.”

 

— Xia Li et al, Effects of perioperative interventions for preventing postoperative delirium

Li X, Wang Y, Liu J, Xiong Y, Chen S, Han J, Xie W, Wu Q. Effects of perioperative interventions for preventing postoperative delirium: A protocol for systematic review and meta-analysis of randomized controlled trials. Medicine. 2021 Jul 7;100(29).

Intraoperative awareness prevention

“…in intravenous anesthesia, BIS monitoring could reduce the incidence of intraoperative awareness by approximately 80%.”

 

— Wen-Wei Gao, et al., in a clinical review on BIS monitoring on interoperative awareness

Gao, Ww., He, Yh., Liu, L. et al. BIS Monitoring on Intraoperative Awareness: A Meta-analysis. Curr Med Sci. 38, 349–353 (2018). doi.org/10.1007/s11596-018-1886-1.

On-demand training

BIS™ Advance monitor training

Learn about the BIS™ Advance monitor at your own pace with our in-depth training modules.

Access training
MedEd Learning Experience podcast series

Discussions on anesthesia and the brain

Explore our interview-style audio and video podcast series on anesthesia and the brain.

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MedEd Bytes video series

Bispectral Index™ monitoring

Watch our “byte”-sized educational video series on Bispectral Index™ monitoring.

Access video series

Software Bill of Materials (SBOM)

To receive the Software Bill of Materials, please email us.

Contact us (open in new window)

Ordering information

Item number Description
PMB4000 BIS™ Advance monitor
PMB4000ACBL BIS™ Advance monitor lock adapter cable
PMB4000BAT BIS™ Advance monitor battery
PMB4000DOC BIS™ Advance docking station
PMB4000PMT BIS™ Advance monitor IV pole mount
PMB4000PWS BIS™ Advance monitor power supply

Resources

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BIS™ Advance Monitor Brochure (open in new window)

Explore the features and benefits of the BIS™ Advance monitor.

PRODUCT PDF 4 MB
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BIS™ Advance Monitor TIVA Brochure (open in new window)

Learn about the use of BIS™ Advance monitor during TIVA procedures.

PRODUCT PDF 1 MB
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BIS™ Advance Monitor ERAS Guidelines Brochure (open in new window)

To inform healthcare professionals of the ERAS society’s recommendation of the BIS™ system and inclusion in their guidelines.

PRODUCT PDF 1 MB
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BIS™ Advance Monitor Postoperative Delirium Brochure (open in new window)

Learn about how BIS™ technology helps to limit postoperative delirium.

PRODUCT PDF 1 MB
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Perioperative Brain Monitoring (Part 1 of 3) White Paper (open in new window)

Part 1 of a white paper on perioperative brain monitoring featuring our BIS™ system.

CLINICAL EVIDENCE PDF 61 KB
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Personalized Dosing in the ICU with BIS™ Brain Monitor Brochure (open in new window)

View information about personalized sedation dosing using the BIS™ monitor in the ICU.

PRODUCT PDF 3 MB
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Perioperative Brain Monitoring (Part 2 of 3) White Paper (open in new window)

Part 2 of a white paper on perioperative brain monitoring featuring our BIS™ system.

CLINICAL EVIDENCE PDF 518 KB
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The Utility of BIS™ Monitoring in Anesthesia for Elderly Patients White Paper (open in new window)

View an AANA Journal June 2024 article featuring the BIS™ Advance monitor.

CLINICAL EVIDENCE PDF 981 KB
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Perioperative Brain Monitoring (Part 3 of 3) White Paper (open in new window)

Part 3 of a white paper on perioperative brain monitoring featuring our BIS™ system.

CLINICAL EVIDENCE PDF 82 KB

Related links

Similar products

The BIS™ monitoring system should not be used as the sole basis for diagnosis or therapy and is intended only as an adjunct in patient assessment. Reliance on the BIS™ monitoring system alone for intraoperative anesthetic management is not recommended.

  1. Lewis SR, Pritchard MW, Fawcett LJ, Punjasawadwong Y. Bispectral index for improving intraoperative awareness and early postoperative recovery in adults. Cochrane Database Syst Rev. 2019;9(9):CD003843.

  1. Gan TJ, Glass PS, Windsor A, et al. Bispectral index monitoring allows faster emergence and improved recovery from propofol, alfentanil and nitrous oxide anesthesia. Anesthesiology. 1997;87(4):808–815. doi:10.1097/00000542-199710000-00014.
  2. BIS™ Advance Monitor Operators Manual. Medtronic; 2023; 95–127.
  3. Punjasawadwong Y, Phongchiewboon A, Bunchungmongkol N. Bispectral index for improving anaesthetic delivery and postoperative recovery. Cochrane Database Syst Rev. 2014;2014(6):CD003843. doi:10.1002/14651858.CD003843.pub3.
  4. Song D, Joshi GP, White PF. Titration of volatile anesthetics using bispectral index facilitates recovery after ambulatory anesthesia. Anesthesiology. 1997;87(4):842–848.
  5. Luginbühl M, Wüthrich S, Petersen-Felix S, Zbinden AM, Schnider TW. Different benefit of bispectal index (BIS) in desflurane and propofol anesthesia. Acta Anaesthesiol Scand. 2003;47(2):165–173.
  6. Klopman MA, Sebel PS. Cost-effectiveness of BIS™pectral index monitoring. Curr Opin Anaesthesiol. 2011; 24(2):177-181)
  7. Shepherd J, Jones J, Frampton G, Bryant J, Baxter L, Cooper K. Clinical effectiveness and cost-effectiveness of depth of anaesthesia monitoring (E-Entropy, BIS™pectral Index and Narcotrend): a systematic review and economic evaluation. Health technol assess. 2013;17(34):1-264.
  8. Wong J, Song D, Blanshard H, Grady D, Chung F. Titration of isoflurane using BIS index improves early recovery of elderly patients undergoing orthopedic surgeries. Can J Anaesth. 2002;49(1):13–18. doi:10.1007/BF03020413.