Exhibiting a significant proportion of asynchronous breaths is associated with an almost five-fold increase in ICU mortality,([FOOTNOTE=Blanch L, Villagra A, Sales B, et al. Asynchronies during mechanical ventilation are associated with mortality. Intensive care medicine. 2015;41(4):633-641.],[ANCHOR=View Abstract],[LINK=content/mitg/websites/languagemasters/emea/en-gb/support/clinical-evidence.html?id=906058]) a three-fold increase in median duration of mechanical ventilation and a greater than two-fold increase in median hospital length of stay.([FOOTNOTE=de Wit M, Miller KB, Green DA, Ostman HE, Gennings C, Epstein SK. Ineffective triggering predicts increased duration of mechanical ventilation. Critical care medicine. 2009;37(10):2740-2745.],[ANCHOR=View Abstract],[LINK=content/mitg/websites/languagemasters/emea/en-gb/support/clinical-evidence.html?id=720867])
Approximately 36% of patients admitted to the ICU require mechanical ventilation.([FOOTNOTE=Dasta JF, McLaughlin TP, Mody SH, Piech CT. Daily cost of an intensive care unit day: the contribution of mechanical ventilation. Critical care medicine. 2005;33(6):1266-1271.],[ANCHOR=View Abstract],[LINK=content/mitg/websites/languagemasters/emea/en-gb/support/clinical-evidence.html?id=959739]) Those patients who endure a prolonged time on mechanical ventilation are at-risk for greater resource utilization and length of stay. ([FOOTNOTE=Zilberberg MD, Luippold RS, Sulsky S, Shorr AF. Prolonged acute mechanical ventilation, hospital resource utilization, and mortality in the United States. Critical care medicine. 2008;36(3):724-730.],[ANCHOR=View Abstract],[LINK=content/mitg/websites/languagemasters/emea/en-gb/support/clinical-evidence.html?id=1203240]) Therefore a great deal of clinical focus has developed around optimizing the delivery of mechanical ventilation and subsequent weaning. An increasing amount of evidence is revealing the relationship between patient-ventilator asynchrony (PAV) and adverse outcome in mechanically ventilated patients including increased time on mechanical ventilation and mortality.1,2 Therefore, the identification, prevention and resolution of patient-ventilator asynchrony is increasingly being recognized as being integral to the optimization of quality of care for mechanically ventilated patients.
Up to 25% of patients with acute respiratory failure exhibit a significant proportion of asynchronous breaths (>10 %)([FOOTNOTE=Robinson BR, Blakeman TC, Toth P, Hanseman DJ, Mueller E, Branson RD. Patient-ventilator asynchrony in a traumatically injured population. Respiratory care. 2013;58(11):1847-1855. ],[ANCHOR=View Abstract],[LINK=content/mitg/websites/languagemasters/emea/en-gb/support/clinical-evidence.html?id=1203233])
Exhibiting a significant proportion of asynchronous breaths is associated with an almost five-fold increase in ICU mortality,1 a three-fold increase in median duration of mechanical ventilation and a greater than two-fold increase in median hospital length of stay.2
Patient-ventilator asynchrony consists of multiple types of asynchrony. The identification and treatment of each type is multifactorial, influenced by a myriad of ventilator-related and patient-specific factors.([FOOTNOTE=Pierson DJ. Patient-ventilator interaction. Respiratory care. 2011;56(2):214-228.],[ANCHOR=View Abstract],[LINK=content/mitg/websites/languagemasters/emea/en-gb/support/clinical-evidence.html?id=1203232])
Reduction of asynchrony may improve patient outcomes compared to PS and VC. ([FOOTNOTE=Bosma K, Ferreyra G, Ambrogio C, et al. Patient-ventilator interaction and sleep in mechanically ventilated patients: pressure support versus proportional assist ventilation. Critical care medicine. 2007;35(4):1048-1054.],[ANCHOR=View Abstract],[LINK=content/mitg/websites/languagemasters/emea/en-gb/support/clinical-evidence.html?id=352110]),([FOOTNOTE=Xirouchaki N, Kondili E, Klimathianaki M, Georgopoulos D. Is proportional-assist ventilation with load-adjustable gain factors a user-friendly mode? Intensive care medicine. 2009;35(9):1599-1603.],[ANCHOR=View Abstract],[LINK=content/mitg/websites/languagemasters/emea/en-gb/support/clinical-evidence.html?id=719463])