NANOSTIM^TM

Synthetic bone paste

Resorbable Nanocrystalline Hydroxyapatite

NANOSTIM™ Synthetic Bone Paste is a water-based bone grafting paste that uses nanotechnology to facilitate new bone formation and bone healing.

Delivered in a syringe, NANOSTIM™ Synthetic Bone Paste is ready to use in the filling and reconstruction of bone defects in orthopaedics, traumatology, and neurosurgery.

Vertebral Interbody Fusion to be used as a bone graft extender.

• Bone graft extender: autograft & allograft, offering the adequate graft volume.
• Low radio-opacity. Allow radiological assessment of new bone formation.
• Easy to use. Good handling.

• Resorbable, by Macrophages & Osteoclast
• Synthetic, nanocrystalline Hydroxyapatite
• Nanocrystalline Structure, facilitates enhanced graft resorption & remodeling
• Osteoconductive, facilitate new bone formation & bone healing
• HA in water-based suspension
• Rapid vascularization & easy invasion of osteogenic cells
• Easy Handling
  • Ready to use, injectable & MIS compatible
  • Excellent mixing properties with all types of bone graft
  • 4 sizes (1cc, 2cc, 5cc and 10cc)

Methodology

• 7 tibial, calcaneal or distal radial fractures treated with plate fixation and nanocrystalline hydroxyapatite
• Biopsy specimens from 6 adult patients at the time of osteosynthesis removal
• Average time point 13 months.

Results

• Cortical and spongious bone well structured
• Implanted material widely absorbed
• In all specimens, new bone formation clearly visible with the deposition of osteoid and mineralization in the presence of cell layers resembling osteoblasts.

See the device manual for detailed information regarding the instructions for use, indications, contraindications, warnings, precautions, and potential adverse events. For further information, contact your local Medtronic representative and/or consult the Medtronic website at medtronic.eu