NOL® MONITORING TECHNOLOGY 

The videos were created by Medasense. Third party brands are trademarks of their respective owners.

1. Meijer, F., Honing, M., Roor, T., Toet, S., Calis, P., Olofsen, E., Martini, C., van Velzen, M., Aarts, L., Niesters, M., Boon, M., Dahan, A. (2020). Reduced postoperative pain using Nociception Level-guided fentanyl dosing during sevoflurane anaesthesia: a randomised controlled trial. British Journal of Anaesthesia, In Press. DOI:https://doi.org/10.1016/j.bja.2020.07.057

2. Fleur S. Meijer, Chris H. Martini, Suzanne Broens, Martijn Boon, Marieke Niesters, Leon Aarts, Erik Olofsen, Monique van Velzen, Albert Dahan. Nociception-guided versus Standard Care during Remifentanil–Propofol Anesthesia: A Randomized Controlled Trial. Anesthesiology (2019); 130:745–755

3. van der Wal I, Meijer F, Fuica R, Silman Z, Boon M, Martini C, van Velzen M, Dahan A, Niesters M and Gozal Y (2023). Front. Pain Res. 3:1086862. Intraoperative use of the machine learning-derived nociception level monitor results in less pain in the first 90 min after surgery.​

4. User manual PMD-200™ Pain Monitoring System, MK2U-02-378 -EN, Revision 4

5. Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet. 2006;367:1618-1625 

6. Gan T. J. (2017). Poorly controlled postoperative pain: prevalence, consequences, and prevention. Journal of pain research, 10, 2287–2298. https://doi.org/10.2147/JPR.S144066

7. van Boekel RLM, Warlé MC, Nielen RGC, Vissers KCP, van der Sande R, Bronkhorst EM, Lerou JGC, Steegers MAH. Relationship between postoperative pain and overall 30-day complications in a broad surgical population: an observational study. Ann Surg 2019;269:856–65.

8. Fletcher D, Stamer UM, Pogatzki-Zahn E, Zaslansky R, Tanase NV, Perruchoud C, Kranke P, Komann M, Lehman T, Meissner W; euCPSP group for the clinical trial network group of the European Society of Anaesthesiology. Chronic postsurgical pain in Europe: an observational study. Eur J Anaesthesiol 2015;32:725–34

9. Lee LA et al., (2015), Postoperative Opioid-induced Respiratory Depression: A Closed Claims Analysis. Anesthesiology 122:659-665. 

10. Smith HS et al., (2014), Opioid induced nausea and vomiting. Eur J Pharmacol, 722:67-78.

11. Fletcher D et al., (2014), Opioid-induced hyperalgesia in patients after surgery: A systematic review and a meta analysis. Br J Anaesth, 112:991-1004

12. Edry, R., Recea, V., Didust, Y. & Sessler, D. I. (2016). Intraoperative validation of the NOL Index, a non-invasive nociception monitor. Anesthesiology, 125, 193-203.

13. Martini, C. H., Boon, M., Broens, S. J. L., Hekkelman, E. F., Oudhoff, L. A., Buddeke, A. W., Dahan, A. (2015). Ability of the Nociception Level (NOL), a multiparameter composite of autonomic signals, to detect noxious stimuli during propofol-remifentanil anesthesia. Anesthesiology, 123, 524-534.

14. Ma D, Ma J, Chen H, Mu D, Kong H, Yu L. Nociception monitors vs. standard practice for titration of opioid administration in general anesthesia: A meta-analysis of randomized controlled trials. Front Med (Lausanne). 2022 Aug 25;9:963185. doi: 10.3389/fmed.2022.963185. PMID: 36091708; PMCID: PMC9454957.

15. Fuica R, Krochek C, Weissbrod R, Greenman D, Freundlich A, Gozal Y. Reduced postoperative pain in patients receiving nociception monitor guided analgesia during elective major abdominal surgery: a randomized, controlled trial. J Clin Monit Comput. 2023 Apr;37(2):481-491. doi: 10.1007/s10877-022-00906-1. Epub 2022 Aug 17. PMID: 35976578; PMCID: PMC9383658.