NOL Pain Response Monitor | Medtronic (UK)

The PMD-200™ monitor that carries the NOL^® - Nociception Level Index^® technology is the only multiparameter nociception monitor for assessing pain levels in anaesthetized patients undergoing surgery to receive both FDA-granted and CE-marked. The NOL^® – Nociception Level index provides an objective, personalized pain-response scale: 0 (nociceptive response) to 100 (extreme nociceptive response) based on artificial intelligence technology. It features an infrastructure for connectivity with any monitor/EMR system.

The NOL - Nociception Level Index^® technology noninvasively quantifies the physiological pain response (nociception) in critical care settings, enabling you to provide a personalized pain treatment according to your patient's anaesthetic needs.

NOL^®-guided analgesia has been proven to:

Help reduce postoperative pain by 33%¹
Reduce intraoperative opioids usage by 30%²
Reduce intraoperative hypotensive events by 80%²
Help patients report less severe pain³

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Persistent postoperative pain is a significant, unmet clinical challenge, as some patients experiencing acute postoperative pain progress to chronic pain^5,6. Severe, long-lasting acute pain following surgery is a major predictor of postoperative complications and chronic postoperative pain^7,8.

Furthermore, excessive analgesia during surgery can lead to hypotension and other complications such as respiratory depression, postoperative nausea and vomiting (PONV), which can extend PACU stay and delay patient recovery^9,10,11.

NOL^® supports personalized analgesic titration, enabling better control of analgesia and helping to reduce complications and adverse effects of overdosage². Additionally, NOL^®-guided analgesia can improve patient outcomes in reducing postoperative pain, thus enhancing patient recovery^1,3.

Leveraging NOL technology, the PMD-200™ monitoring device developed by Medasense quantifies and visualizes the patient’s physiological response to pain (nociception)⁴.

The PMD-200 is designed for the operating room and critical care settings, where patients under general anesthesia are unable to communicate their pain. The system enables clinicians to assess nociception and objectively titrate analgesics to meet the patient’s specific needs with optimized timing and dosage^1-4.

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1. ACQUIRE → 2. ANALYZE → 3. QUANTIFY → 4. OPTIMAL PAIN CARE

ACQUIRE

The non-invasive platform continuously acquires physicological signals through 4 sensors. Dozens of physiological parameters and derivatives are extracted⁴.

ANALYZE

Advanced artificial intelligence algorithms identify the pain-related pattern⁴

QUANTIFY

The information is quantified and visualized with the NOL® index on a scale of 0 (no nociceptive response) to 100 (extreme nociceptive response)⁴

OPTIMAL PAIN CARE

NOL® guides clinicians to ensure optimal pain control while avoiding overmedication⁴

Potential to Reduce Post-Operative Complications

By optimizing analgesic administration in critical care, NOL^®-guided analgesia might enhance the patient experience as it reduces the risk of excessive use or underuse of opioids and associated complications.⁹

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While hypnosis and muscle relaxation can be continuously and specifically monitored during anaesthesia, analgesia has generally been assessed indirectly through changes in heart rate (HR), blood pressure (BP) and other parameters. However, studies have shown that HR and BP are poor surrogates for assessing nociception and adequacy of analgesia^12,13.

Activation of the sympathetic nervous system due to various stimuli results in a range of physiological responses related to pain, each with different patterns and interactions. To address this complexity, the Nociception Level (NOL) index was developed, integrating multiple autonomic signals into a single composite measure to reflect a patient's analgesic needs⁴.

NOL is based on artificial intelligence technology that quantifies the individual physiological response to pain in real-time, continuously and noninvasively⁴.

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NOL^® Monitoring Technology Optimize pain management

Maintain optimal analgesia

Now, CE marked and FDA granted!

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Analgesia Optimization

Our Solution to Monitor Pain

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