Bradyarrhythmia Management
Clinical Studies and Outcomes
DANISH II
DANISH II
A RANDOMIZED COMPARISON OF ATRIAL AND DUAL-CHAMBER PACING IN 177 CONSECUTIVE PATIENTS WITH SICK SINUS SYNDROME: ECHOCARDIOGRAPHIC AND CLINICAL OUTCOME.
Nielsen JC, Kristensen L, Andersen HR, Mortensen PT, Pedersen OL, Pedersen AK.
JACC. 2003;42(4):614-623
Design: 177 consecutive patients with sick sinus syndrome (SSS) randomized to pacing treatment in AAIR or DDDR with a short AV delay (DDDR-S) or DDDR with a fixed long AV delay (DDDR-I).
Objectives: Compare AAI and DDD pacing in patients with SSS, as measured by echocardiography.
Key Results: Mean Follow-up – 2.9 ± 1.1 years:
- In both DDDR groups, LA diameter increased significantly (P < 0.05)
- In the DDDR-S group, LV fractional shortening decreased significantly (p < 0.01)
- Atrial fibrillation (AF) was significantly less common in the AAIR group (7.4% vs. 17.5% in DDDR-I group and 23.3% in DDDR-S group, p = 0.03, log rank test)
- In the AAIR group, no significant changes were observed in LA or LV diameters