NanoStim™ Synthetic bone paste
Resorbable Nanocrystalline Hydroxyapatite

NanoStim™ Synthetic Bone Paste is a water-based bone grafting paste that uses nanotechnology to facilitate new bone formation and bone healing.

Delivered in a syringe, NanoStim™ Synthetic Bone Paste is ready to use in the filling and reconstruction of bone defects in orthopaedics, traumatology, and neurosurgery.

Vertebral Interbody Fusion to be used as a bone graft extender.

• Bone graft extender: autograft & allograft, offering the adequate graft volume.
• Low radio-opacity. Allow radiological assessment of new bone formation.
• Easy to use. Good handling.

• Resorbable, by Macrophages & Osteoclast
• Synthetic, nanocrystalline Hydroxyapatite
• Nanocrystalline Structure, facilitates enhanced graft resorption & remodeling
• Osteoconductive, facilitate new bone formation & bone healing
• HA in water-based suspension
• Rapid vascularization & easy invasion of osteogenic cells
• Easy Handling
  • Ready to use, injectable & MIS compatible
  • Excellent mixing properties with all types of bone graft
  • 4 sizes (1cc, 2cc, 5cc and 10cc)

Methodology

• 7 tibial, calcaneal or distal radial fractures treated with plate fixation and nanocrystalline hydroxyapatite
• Biopsy specimens from 6 adult patients at the time of osteosynthesis removal
• Average time point 13 months.

Results

• Cortical and spongious bone well structured
• Implanted material widely absorbed
• In all specimens, new bone formation clearly visible with the deposition of osteoid and mineralization in the presence of cell layers resembling osteoblasts.