Symplicity Spyral™ renal denervation system
For treating hypertension
The Symplicity Spyral™ renal denervation system complements medication and lifestyle changes with an effective, evidence-based procedural approach to hypertension treatment.¹⁻⁴
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Extensive clinical evidence
The Symplicity Spyral system is proven to achieve safe and clinically meaningful blood pressure reduction in multiple clinical trials and a real-world patient registry.1-4
Take action on hypertension
Gain access to training, education, and tools to successfully introduce the Symplicity Spyral system to your referring community and patients.
1
Böhm M, Kario K, Kandzari DE, et al. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. The Lancet. 2020;395:1444–1451.
2
Mahfoud F, Kandzari DE, Kario K, et al. Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial. The Lancet. Published online April 4, 2022.
3
Mahfoud F, Mancia G, Schmieder R, et al. Three-year safety and efficacy in the Global Symplicity Registry: Impact of antihypertensive medication burden on blood pressure reduction. Presented at PCR e-course 2020.
4
Kandzari DE, Böhm M, Mahfoud F, et al. Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial. The Lancet. 2018;391(10137):2346–2355.