Note: Ai sensi e per gli effetti dell’Art. 76 D.P.R. 445/2000 consapevole della responsabilità e delle conseguenze civili e penali previste in caso di dichiarazioni mendaci e/o formazione od uso di atti falsi, nonché in caso di esibizione atti contenenti dati non più corrispondenti a verità e consapevole altresì che qualora emerga la non veridicità del contenuto della presente decadranno i benefici per i quali la stessa è rilasciata confermo di essere un OPERATORE SANITARIO.
I contenuti presenti in questo sito contengono informazioni rivolte agli operatori sanitari, in quanto si riferiscono a prodotti rientranti nella categoria dei dispositivi medici che richiedono l’impiego o l’intervento da parte di professionisti del settore medico-sanitario.
EpiFilm and EpiDisc Otologic Laminae are bioresorbable film scaffolds with thousands of microperforations that help the body repair and regrow tissue after middle ear surgery.
EpiFilm® and EpiDisc® Otologic Laminae are bioresorbable, implantable ear packing and patching devices composed of esterified hyaluronic acid (HYAFF®).
After a tympanoplasty, EpiFilm Otologic Lamina has been shown to aid the healing of the mastoid cavity. The 2.5 cm x 2.5 cm matrix is useful for myringoplastic and tympanoplastic procedures, such as:
Covering exposed ear canal walls
Reconstruction of the tympanic membrane when used with fascia or other tissue graft techniques
Lining the mastoid cavity
EpiDisc Otologic Lamina
EpiDisc Otologic Lamina is a pre-cut 8.0 mm disc of EpiFilm lamina, packaged 2 per box. This makes it ideal for use during tympanoplasties or repairing tympanic membrane perforations.
Hyaluronic Acid and Middle Ear Surgery
In middle ear surgery, biocompatible1-7 hyaluronic acid has been shown to improve the natural healing of the mastoid cavity following tympanoplasty and help reduce fibrous scarring.1-4
HYAFF® is a registered trademark of Anika Therapeutics SRL.
References
1
Sayin I, Kaya KH, Ekizoğlu O, Erdim I. A prospective controlled trial comparing spontaneous closure and EpiFilm patching in traumatic tympanic membrane perforations. Eur Arch Otorhinolaryngol. 2012. Epub: 2013 January 5. doi: 10.1007/s00405-012-2331-x.
2
Saliba I, Knapik M, Froehlich P, Abela A. Advantages of hyaluronic acid fat graft myringoplasty over fat graft myringoplasty. Arch Otolaryngol Head Neck Surg. 2012; 138(10):950-955.
3
Martini A, Morra B. Use of a hyaluronan-based biomembrane in the treatment of chronic cholesteatomatous otitis media. Am J Otology. 2000; 21:468-473.
4
Laurent C, Hellstrom S, Stenfors L. Hyaluronic acid reduces connective tissue formation in middle ears filled with absorbable gelatin sponge: an experimental study. Am J Otolaryngol. 1986; 7:181-186.
5
Pirnazar P, et al. Bacteriostatic effects of hyaluronic acid. J Periodontol. 1999; 70:370-374.
6
Longaker MT, et al. Studies in fetal wound healing. A prolonged presence of hyaluronic acid characterized wound fluid. Annals of Surgery. 1991; 213:292-296.
7
Grainger DA, et al. The use of hyaluronic acid polymers to reduce postoperative adhesions. J Gynecol Surg. 1991; 7:97-101.
EpiFilm® and EpiDisc® Otologic Laminae are unique bioresorbable, implantable ear packing and patching devices composed of esterified hyaluronic acid, or HYAFF®. The thin film scaffold acts as a temporary matrix for cell proliferation, working with the body’s natural healing process to repair and regrow damaged tissue.
Thousands of microperforations enable cells to migrate across and through the scaffold, populating both sides simultaneously and facilitating drainage.
By providing a multilayer, thick cell structure in a shorter period of time, EpiFilm and EpiDisc Otologic Laminae physically enhance the epithelialization process. In approximately 6-8 weeks, the temporary scaffold is resorbed.
In middle ear surgery, hyaluronic acid has been shown to improve the natural healing of the mastoid cavity following tympanoplasty and help reduce fibrous scarring.1-4
Hyaluronic acid is a linear polysaccharide and naturally occurring constituent of the extracellular matrix.
It plays a significant role in the body during the repair process, mediating cell adhesion, differentiation, motility, and blood vessel growth. Hyaluronic acid has a well-established biocompatibility profile.1-7
HYAFF® is a registered trademark of Anika Therapeutics SRL.
References
1
Sayin I, Kaya KH, Ekizoğlu O, Erdim I. A prospective controlled trial comparing spontaneous closure and EpiFilm patching in traumatic tympanic membrane perforations. Eur Arch Otorhinolaryngol. 2012. Epub: 2013 January 5. doi: 10.1007/s00405-012-2331-x.
2
Saliba I, Knapik M, Froehlich P, Abela A. Advantages of hyaluronic acid fat graft myringoplasty over fat graft myringoplasty. Arch Otolaryngol Head Neck Surg. 2012; 138(10):950-955.
3
Martini A, Morra B. Use of a hyaluronan-based biomembrane in the treatment of chronic cholesteatomatous otitis media. Am J Otology. 2000; 21:468-473.
4
Laurent C, Hellstrom S, Stenfors L. Hyaluronic acid reduces connective tissue formation in middle ears filled with absorbable gelatin sponge: an experimental study. Am J Otolaryngol. 1986; 7:181-186.
5
Pirnazar P, et al. Bacteriostatic effects of hyaluronic acid. J Periodontol. 1999; 70:370-374.
6
Longaker MT, et al. Studies in fetal wound healing. A prolonged presence of hyaluronic acid characterized wound fluid. Annals of Surgery. 1991; 213:292-296.
7
Grainger DA, et al. The use of hyaluronic acid polymers to reduce postoperative adhesions. J Gynecol Surg. 1991; 7:97-101.
