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Medtronic / Covidien Products / Capsule Endoscopy / PillCam Crohns

Comprehensive Crohn’s disease monitoring.

With a single capsule.

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Why capsule endoscopy?

Capsule endoscopy offers several benefits:

  • Demonstrated greater sensitivity for detecting proximal small bowel lesions1
  • Detected more extensive Crohn’s disease activity in 63% of patients who received an alternate imaging study at diagnosis2
  • Enables detection of even subtle mucosal changes3
  • Mucosal healing can lead to fewer surgeries, long-term clinical remission, and fewer hospitalizations4

Features

The PillCam™ Crohn’s system allows to noninvasively and directly visualizes the small bowel and colonic mucosa with one procedure.5,6 It enables efficient visualization of Crohn’s disease activity. Compared to traditional modalities, you can expect to see several advantages with this advanced system in your practice today.

  • May support greater clinical and economic efficiency by reducing the need for multiple procedures6,8
  • May increase patient satisfaction9,12 by offering a noninvasive solution that does not require sedation or radiation9,10

Technology

Featuring advanced optics and additional coverage to capture detailed images, the PillCam™ Crohn’s system enables pan-intestinal visualization through these features11:

  • Adaptive frame rate technology obtains comprehensive visualization in areas of fast transit by capturing images up to 35 frames per second
  • Field of view that allows for a 344° view between both capsule heads, providing complete coverage of the small bowel and colon
  • PillCam™ software v9 can make the interpretation of results convenient with the new, improved, and simple-to-use graphic user interface
  • Compatible with the PillCam™ patency system.

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References

Risk Information: The risks of the PillCam™ Crohn’s capsule include capsule retention, aspiration, and skin irritation. The risks associated with colon preparation are allergies or other known contraindications to any preparation agents or medications used for the PillCam™ Crohn’s system regimen, according to laxative medication labeling and per physician discretion. Medical, endoscopic, or surgical intervention may be necessary to address any of these complications, should they occur. After ingesting the PillCam™ Crohn’s capsule, and until the capsule is excreted, patients should not be near any source of powerful electromagnetic fields, such as one created near an MRI device. Please refer to the product user manual or pillcamcrohnscapsule.eu for detailed information.

1. Flamant M, Trang C, Maillard O, Sacher-Huvelin S, Le Rhun M, Galmiche JP, et al. The prevalence and outcome of jejunal lesions visualized by small bowel capsule endoscopy in Crohn’s disease. Inflamm Bowel Dis. 2013 Jun;19(7):1390-6

2. Min SB, Le-Carlson M, Singh N, Nylund CM, Gebbia J, Haas K, et al. Video capsule endoscopy impacts decision making in pediatric IBD: a single tertiary care center experience. Inflamm Bowel Dis. 2013 Sep;19(10)2139-45.

3. Dionisio PM, Gurudu SR, Leighton JA, Leontiadis GI, Fleischer DE, Hara AK, et al. Capsule endoscopy has a significantly higher diagnostic yield in patients with suspected and established small-bowel Crohn’s disease: a meta-analysis. Am J Gastroenterol. 2010;105:1240-8.

4. Reinink ARR, Lee TC, Higgins PDR. Endoscopic mucosal healing predicts favorable clinical outcomes in inflammatory bowel disease: a meta-analysis. Inflamm Bowel Dis. 2016 Aug;22(8):1859-69.

5. Factual Statement- Internal Competitive Analysis

6. Bruining, David Henry, et al. Panenteric capsule endoscopy versus ileocolonoscopy plus magnetic resonance enterography in Crohn’s disease: a multicentre, prospective study. BMJ open gastroenterology, 2020, 7.1: e000365.

7. Saunders, Rhodri, et al. Validation of a Model Estimating the Budget Impact of Video Capsule Endoscopy for Surveillance of Crohn’s Disease in an Italian Center. Journal of Health Economics and Outcomes Research, 2024, 11.1: 67.

8. Lobo, Alan, et al. Economic analysis of the adoption of capsule endoscopy within the British NHS. International Journal for Quality in Health Care, 2020, 32.5: 332-341.

9. Lahat, Adi, et al. Magnetic resonance enterography or video capsule endoscopy–what do Crohn’s disease patients prefer?. Patient preference and adherence, 2016, 1043-1050.

10. D’Haens, Geert, et al. Safety and feasibility of using the second-generation Pillcam colon capsule to assess active colonic Crohn’s disease. Clinical Gastroenterology and Hepatology, 2015, 13.8: 1480-1486. e3.

11. PillCamTM Capsule Endoscopy User Manual PillCamTM Desktop Software Version 9.0 DOC-2928-03 July 2020.

12. Parodi A, Vanbiervliet G, Hassan C, Hebuterne X, De Ceglie A, Filiberti RA, Spada C, Conio M. Colon capsule endoscopy to screen for colorectal neoplasia in those with family histories of colorectal cancer. Gastrointest Endosc. 2018 Mar;87(3):695-704. doi: 10.1016/j.gie.2017.05.023. Epub 2017 May 26. PMID: 28554656.