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Innovation in Endoscopic Hemostasis

Management of Patients with Gastrointestinal Bleeding

What is Nexpowder™*?

2:41

Clinical Education

NexpowderTM* Online Training

Available now

In this online training, you will learn about:

  • NexpowderTM* product and technology 
  • NexpowderTM* clinical efficiency 
  • Indications for NexpowderTM*
  • Product handling
  • Best practice
Register here

In-Service Information

 NexpowderTM* Endoscopic Hemostatic System

These instructions provide a step-by-step guide on how to setup and use the NexpowderTM*  Endoscopic Hemostatic System. 

Watch the Instructional Video or download the Procedural Guide.

Download the Procedural Guide

Clinical Experience

Nexpowder™* applied in Upper and Lower GI 

In this video, Dr. Beyna discusses his experience with NexpowderTM* in two separate cases, one in the lower GI and one in the upper GI area, and how NexpowderTM* can be applied in both active and non-active bleeding.

*This video was created in EU and may contain products that are not available in Canada.

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Nexpowder™* to prevent rebleeding

In this video Dr.  Beyna, demonstrates the assembly of the NexpowderTM* components and using the system on a bleeding site. Upon deployment, NexpowderTM* transforms into a highly adhesive gel that creates a mechanical barrier.

*This video was created in EU and may contain products that are not available in Canada.

Watch now

Nexpowder™* cases

In this video you can watch an overview of NexpowderTM* being applied in the following cases:

  • Peptic ulcer bleeding
  • Gastric cancer bleeding
  • Post-gastric ESD bleeding
  • Salvage therapy ESD bleeding

*This video was created in EU and may contain products that are not available in Canada.

Watch now

Would you like to learn more?

Maximum Control. Minimal Clogging.

Hemostatic powder technology that puts you in control.3,4,5

The Nexpowder™* endoscopic hemostasis system is a powder that can be sprayed to an ulcer site, applying an endoscopic hemostatic agent. As a hydrophilic biocompatible adhesive material, it is composed of succinic anhydride (ε-poly-(L-lysine)) and oxidized dextran. 

The Nexpowder™* system forms the adhesive gel after making contact with the water or blood by reversible crosslinking. Crosslinked gel helps prevent bleeding, loss of body fluid and contamination of the ulcer site by adhering to the bleeding site in the gastrointestinal tract and then gel degrades within 1 day to 3 days.3,4,5

Download the product brochure

INTENDED USE

The Nexpowder™ hemostatic system for endoscopy is used for most types of GI bleeding. The device is applied during an endoscopic procedure and can cover ulcer or bleeding sites. The device is not intended for use in patients with variceal bleeding.

CONTRAINDICATIONS

Because the Nexpowder™* system includes lactose, it is contraindicated in patients who have galactose intolerance, lapp lactase deficiency, or glucose-galactose malabsorption and they would be at risk of having nausea, bloating, and diarrhoea. Because the Nexpowder™* system includes Brilliant Blue FCF, it must not be used in patients with known hypersensitivity to brilliant blue FCF.
For a full indications of use, contraindications, precautions, warnings, and potential adverse events, please refer to the Instructions for Use.

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  • ™* Third party brands are trademarks of their respective owners. All other brands are trademarks of a Medtronic company

  • 1. Antunes C, Copelin II EL. Upper Gastrointestinal Bleeding. [Updated 2019 Sep 30]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470300/

  • 2. Raphaeli T, Menon R. Current treatment of lower gastrointestinal hemorrhage. Clin Colon Rectal Surg. 2012;25(4):219-227. doi:10.1055/s-0032-1329393

  • 3. Park JS, Kim HK, Shin YW, et al. Novel hemostatic adhesive powder for nonvariceal upper gastrointestinal bleeding. Endosc Int Open. 2019 Dec; 7(12):E1763-E1767.

  • 4. Park JS, Bang BW, Hong SJ, et al. Efficacy of a novel hemostatic adhesive powder in patients with refractory upper gastrointestinal bleeding: a pilot study. Endoscopy. 2019 May; 51(5):458-462.

  • 5. Bang B, Lee E, Maeng J, et al. Efficacy of a novel endoscopically deliverable muco-adhesive hemostatic powder in an acute gastric bleeding porcine model. PLoS One. 2019 Jun 11; 14(6):e0216829.

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