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Atrial Fibrillation Patient

SUSPECTED ATRIAL FIBRILLATION CARDIAC DIAGNOSTICS & MONITORING

Make the connection between atrial fibrillation and stroke for patients at high risk

Atrial Fibrillation & Stroke:
A Global Health Challenge

Atrial fibrillation (AF or AFib) is the most common sustained heart rhythm disorder and increases the risk for heart disease and stroke, both leading causes of death1

Atrial Fibrillation Impact Chart

AF Detection and Treatment Matters

AF Detection Matters Chart

DIFFICULTIES IN AF DETECTION

AF Detection Difficulties Chart

Short-term and intermittent cardiac monitoring may miss many patients with paroxysmal AF6-8

  • Short-term monitoring via 24-hour Holter has low sensitivity and negative predictive value for AF detection.6
  • Intermittent and symptom-based monitoring has a significantly lower sensitivity and negative predictive value for AF detection compared with continuous monitoring.7

Longer, continuous monitoring periods result in higher AF detection.8

AF & STROKE: SIMILARITIES AMONG RISK FACTORS9,10

CHADS2 Score: Evaluates ischemic stroke risk in patients with AF CHA2DS2-VASc Score: Evaluates ischemic stroke risk in patients with AF
  • Congestive heart failure
  • Hypertension
  • Age
  • Diabetes
  • Stroke/TIA/ thromboembolism
  • Congestive heart failure
  • Hypertension
  • Age
  • Diabetes
  • Stroke/TIA/ thromboembolism
  • Vascular disease
  • Sex 
1

World Heart Federation statistics. http://www.world-heart-federation.org/cardiovascular-health/stroke/.

2

Benjamin EJ, Blaha MJ, Chiuve SE, et al. Heart Disease and Stroke Statistics — 2017 Update. A Report From the American Heart Association. Circulation. March 7, 2017;135(10):e146-e603.

3

Lin HJ, Kelly-Hayes M, Beiser AS, et al. Stroke severity in atrial fibrillation: The Framingham Study. Stroke. October 1996;27(10):1760-1764.

4

Stroke Prevention in Atrial Fibrillation Study. Final results. Circulation. August 1991;84(2):527-539.

5

Strickberger, SA, Ip J, Saksena S, et al. Relationship between atrial tachyarrhythmias and symptoms. Heart Rhythm. February 2005;2(2):125-131.

6

Hanke T, Charitos EI, Stierle U, et al. Twenty-four-hour holter monitor follow-up does not provide accurate heart rhythm status after surgical atrial fibrillation ablation therapy: up to 12 months experience with a novel permanently implantable heart rhythm. September 15, 2009;120(11 Suppl):S177-184

7

Ziegler PD, Koehler JL, Mehra R. Comparison of continuous versus intermittent monitoring of atrial arrhythmias. Heart Rhythm. December 2006;3(12):1445-1452.

8

Jabaudon D, Sztajzel J, Sievert K, Landis T, Sztajzel R. Usefulness of ambulatory 7-day ECG monitoring for the detection of atrial fibrillation and flutter after acute stroke and transient ischemic attack. Stroke. July 2004;35(7):1647-1651.

9

January CT, et al.2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: Executive Summary. Circulation. 2014; 23(130): 2071-2104

10

Kirchhof P, et al. 2016 ESC Guidelines for the Management of Atrial Fibrillation. Europace. 2016; 11(18): 1609-1678.