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Symplicity Spyral System
for hypertension
The Symplicity Spyral renal denervation (RDN) system complements medications and lifestyle modifications for the management of hypertension.
During the Symplicity™ blood pressure procedure, an interventionalist uses the Symplicity Spyral RDN system to supply precisely controlled and targeted RF energy to the renal nerves, safely disrupting the overactive sympathetic signaling between the kidneys and brain to help reduce blood pressure.1
25,000 patients around the globe have been treated with the Symplicity Spyral RDN System.2
Symplicity™ Blood Pressure Procedure Video - (04:10)
See how the Symplicity Spyral™ renal denervation system works to help lower blood pressure.
More information (see more)
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Results may vary.
Contact your Medtronic sales representative to discuss availability.
Catalog number |
Description |
---|---|
RDN016 |
Symplicity Spyral multi-electrode Renal Denervation catheter |
RDNG3A |
Symplicity G3 generator • supplied standard with remote control |
RDN019 |
Mobile cart for Symplicity G3 generator (optional accessory) |
SB6RDND1K |
Sherpa NX™ Balanced 6F 55 cm guide catheter with RDND1 curve |
LA6IMAK |
Launcher™ 6F 55 cm guide catheter with IMA curve |
SB6IMAK |
Sherpa NX™ Balanced 6F 55 cm guide catheter with IMA curve |
E7507 E7507DB |
Dispersive electrode for RDNG3A: Compatible with Covidien ValleyLab Polyhesive™ adult patient return electrode |
Our goal is to support you and your practice as you become familiar with this emerging therapy.
The Symplicity Spyral RDN system is backed by multiple sham-controlled trials and a real-world registry.
Learn more about the turning point in hypertension care and how it can help enhance management strategies.
Includes Symplicity Spyral and Flex™ catheters.
Study follow-up is ongoing. Data does not represent follow-up for all patients.
Catheter dimension of 0.052" is average maximum diameter determined during design verification. Upper bound allowable is 0.061".
Medtronic Symplicity Spyral multi-electrode renal denervation catheter instructions for use.
Based on internal RDN catheter historical data. June 2023. Data includes both Symplicity Flex and Symplicity Spyral.
Böhm M, Kario K, Kandzari DE, et al. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. Lancet. 2020;395(10234):1444–1451.
Kandzari D, Townsend R, Kario K, et al. Safety and efficacy of renal denervation in patients taking antihypertensive medication. J Am Coll Cardiol. 2023;82(19):1809–1823.
Mahfoud F, Mancia G, Schmieder R, et al. Outcomes following radiofrequency renal denervation according to antihypertensive medications: subgroup analysis of the Global SYMPLICITY Registry DEFINE. EuroPCR 2023.
Mahfoud F, Kandzari DE, Kario K, et al. Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial. Lancet. 2022;399(10333):1401–1410.
Coates P, Tunev S, Trudel J, Hettrick DA. Time, temperature, power, and impedance considerations for radiofrequency catheter renal denervation. Cardiovasc Revasc Med. 2022;42:171–177.
Sato Y, Sharp A, Mahfoud F, et al. Translational value of preclinical models for renal denervation: a histological comparison of human versus porcine renal nerve anatomy. EuroIntervention. 2023;18(13):e1120–e1128.
García-Touchard A, Maranillo E, Mompeo B, Sañudo JR. Microdissection of the Human Nervous System: Implications for Performing Renal Denervation Procedures. Hypertension. 2020;76(4):1240–1246.
Struthoff H, Lauder L, Hohl M, et al. Histological examination of renal nerve distribution, density, and function in humans. EuroIntervention. 2023;19(7):612–620.