Resolute Onyx DES for coronary artery disease
Resolute Onyx™ is a drug-eluting stent (DES) that's different by design, optimised for complex PCI, and proven safe and effective in real-world, high bleeding risk patients on 1-month dual antiplatelet therapy (DAPT).1
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Overview
Product Features
Best-in-class deliverability
Single-wire design
Resolute Onyx DES is made from a single wire, which gives it a fluid range of motion and provides the flexibility needed for best-in-class deliverability.2
Sinusoid-formed wire
Helical wrap
Laser-fused
The Only DES Designed from a Single Wire‡
- Single-wire design provides a fluid range of motion and the conformability needed for superior strut apposition.2
- BioLinx biocompatible polymer provides superior thromboresistance.4
- When combined, fast healing occurs as evidenced by nearly 90% strut coverage at 30 days,3 providing the foundation for the Onyx ONE Global Trial.
- The Onyx ONE Global Trial analysed real-world, high bleeding risk patients on 1-month DAPT treated with a Resolute Onyx DES or a BioFreedom™* DCS.
- Results showed Resolute Onyx DES was safe and effective,1 providing the option to shorten DAPT in patients who are at high bleeding risk.
- Based on these results, Resolute Onyx DES was the first DES CE-indicated for HBR patients on 1-month DAPT.
Enhanced visibility with thinner struts
Platinum-iridium core within Resolute Onyx DES increases visibility for accurate stent placement without compromising strut thickness.2
Resolute Onyx cobalt alloy shell and platinum-iridum core
- Cobalt alloy shell
- Platinum iridium core
Smooth side branch access
Resolute Onyx DES has round struts to create a smooth passage when accessing the side branch and lower the propensity to catch during bifurcation procedures.2
Rounded strut cross-section
- Resolute Onyx DES
Broadest diameter range
- Complex PCI requires a broad DES size matrix to match a wide range of patient anatomies.
- Resolute Onyx is the only DES with diameters ranging from 2.0 mm to 5.0 mm to treat a broad range of coronary vessel sizes.
| Diameter (mm) |
Stent Length (mm) |
Maximum Expansion |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 2.00 |
8 |
12 |
15 |
18 |
22 |
26 |
30 |
— |
— |
3.50‡ |
| 2.25 |
8 |
12 |
15 |
18 |
22 |
26 |
30 |
34 |
38 |
3.50‡ |
| 2.50 |
8 |
12 |
15 |
18 |
22 |
26 |
30 |
34 |
38 |
3.50‡ |
| 2.75 |
8 |
12 |
15 |
18 |
22 |
26 |
30 |
34 |
38 |
4.00‡ |
| 3.00 |
8 |
12 |
15 |
18 |
22 |
26 |
30 |
34 |
38 |
4.00‡ |
| 3.50 |
8 |
12 |
15 |
18 |
22 |
26 |
30 |
34 |
38 |
5.00‡ |
| 4.00 |
8 |
12 |
15 |
18 |
22 |
26 |
30 |
34 |
38 |
5.00‡ |
| 4.50 |
— |
12 |
15 |
18 |
22 |
26 |
30 |
— |
— |
6.00‡ |
| 5.00 |
— |
12 |
15 |
18 |
22 |
26 |
30 |
— |
— |
6.00‡ |
Product Details
| Stent Diameter (mm) | Stent Length (mm) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 8 | 12 | 15 | 18 | 22 | 26 | 30 | 34 | 38 | |
| 2.00 | RONYX20008X | RONYX20012X | RONYX20015X | RONYX20018X | RONYX20022X | RONYX20026X | RONYX20030X | N/A | N/A |
| 2.25 | RONYX22508X | RONYX22512X | RONYX22515X | RONYX22518X | RONYX22522X | RONYX22526X | RONYX22530X | RONYX22534X | RONYX22538X |
| 2.50 | RONYX25008X | RONYX25012X | RONYX25015X | RONYX25018X | RONYX25022X | RONYX25026X | RONYX25030X | RONYX25034X | RONYX25038X |
| 2.75 | RONYX27508X | RONYX27512X | RONYX27515X | RONYX27518X | RONYX27522X | RONYX27526X | RONYX27530X | RONYX27534X | RONYX27538X |
| 3.00 | RONYX30008X | RONYX30012X | RONYX30015X | RONYX30018X | RONYX30022X | RONYX30026X | RONYX30030X | RONYX30034X | RONYX30038X |
| 3.50 | RONYX35008X | RONYX35012X | RONYX35015X | RONYX35015X | RONYX35022X | RONYX35026X | RONYX35030X | RONYX35034X | RONYX35038X |
| 4.00 | RONYX40008X | RONYX40012X | RONYX40015X | RONYX40018X | RONYX40022X | RONYX40026X | RONYX40030X | RONYX40034X | RONYX40038X |
| 4.50 | N/A | RONYX45012X | RONYX45015X | RONYX45018X | RONYX45022X | RONYX45026X | RONYX45030X | N/A | N/A |
| 5.00 | N/A | RONYX50012X | RONYX50015X | RONYX50018X | RONYX50022X | RONYX50026X | RONYX50030X | N/A | N/A |
Maximum expansion capabilities
For reference only in markets where the Resolute Onyx coronary stent and the 0.25 mm expansion have been approved.
Additional Resources
Onyx ONE Global Trial
First randomised, 1-month DAPT trial comparing a DES to a DES in ~2000 high bleeding risk patients on 1-month DAPT.
Review the DataResolute Onyx DES is optimised for complex PCI
Resolute Onyx DES design exclusives make it ideal for complex cases.
See HowBifurcation education
View five techniques that highlight Resolute Onyx DES through endoscopic imaging captured inside an isolated and reanimated beating porcine heart.
Visit and BookmarkThe Resolute Onyx DES zotarolimus drug effectively inhibits neointimal growth while the exclusive, highly biocompatible BioLinx™ polymer contributes to minimal inflammation, low thrombotic risk,5 as well as rapid, complete, and functional endothelial healing.§4
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*
As per April 2021.
†
Medtronic and Medtronic logo are trademarks of Medtronic. Third-party trademarks ("™†") belong to their respective owners. All other brands are trademarks of a Medtronic entity.
‡
Including Resolute Integrity™ DES, part of the Medtronic DES portfolio.
§
In porcine models.
References
1
Windecker S, Latib A, Kedhi E, et al. Polymer-based or Polymer-free Stents in Patients at High Bleeding Risk. N Engl J Med. March 26, 2020;382(13):1208-1218.
2
Based on bench test data on file at Medtronic. May not be indicative of clinical performance.
3
Roleder T, Kedhi E, Berta B, et al. Short-term stent coverage of second-generation zotarolimus-eluting durable polymer stents: Onyx one-month optical coherence tomography study. Adv Interv Cardiol. 2019;15(2):143-150.
4
Jinnouchi H, Sato Y, Cheng Q, et al. Int J Cardiol. March 2021;327:52-57.