OnyxTM Liquid
Embolic System
for peripheral embolization
The Onyx™ Liquid Embolic System is an ethylene vinyl alcohol (EVOH) copolymer dissolved in dimethyl sulfoxide (DMSO) for peripheral embolization.
Overview
The OnyxTM Liquid Embolic System (LES) is an ethylene vinyl alcohol (EVOH) copolymer that provides complete filling and distal penetration1 of peripheral lesions. Its non-adhesive properties permit more distal nidus embolization without significant risk of catheter entrapment, while higher viscosities allow for controlled deployment.2
Indications
OnyxTM 18 and 34 LES: Embolization of lesions in the peripheral vasculature, including arteriovenous malformations, and hypervascular tumors.
OnyxTM 34L LES: Embolization of lesions in the peripheral vasculature, including endoleaks, arteriovenous malformations, portal veins, bleeding, and tumors.
Product details
OnyxTM is a non-adhesive liquid embolic agent composed of EVOH dissolved in DMSO with suspended micronized tantalum powder. It is delivered through a microcatheter under fluoroscopic control.
Polymeric properties
- Precipitation occurs on contact with aqueous solution (e.g., blood, water, contrast)
- Flows like lava and solidifies from the outside in as solvent diffuses away
- Delivers in a cohesive manner, forming a spongy, coherent embolus
Controlled delivery
- Slow, controlled injection and delivery method
- Ability to start and stop injections (pauses should not exceed two minutes)
- Cohesive deposition and delivery
- Excellent visibility3
- Controlled angiography during embolic injection
Formulations
OnyxTM 18 and 34 LES for peripheral use:
- OnyxTM 18 LES (6% EVOH, viscosity of 18 cSt): travels more distally and penetrates deeper into the targeted lesion due to its lower viscosity compared to OnyxTM 34 (i.e., peripheral AVM nidus)
- OnyxTM 34 LES (8% EVOH, viscosity of 34 cSt): has higher viscosity for more control in higher flow and large fistulous components
OnyxTM 34L LES for peripheral use:
- 8% EVOH, viscosity of 34 cSt
- Lower tantalum content than current version of OnyxTM 34 LES4
- Less streak artifact on CT with good visibility during injection4
OnyxTM 34L LES packaging with 6 mL vial
- 6 mL vial provides ease of use for large-volume treatments
- Requires less storage space than four 1.5 mL vials of OnyxTM 34 LES
- Environmentally friendly packaging made from 98% recyclable content
Hemorrhage case
Watch this case overview of a patient with lower gastrointestinal bleeding.
OnyxTM publication summaries
CT validation
OnyxTM 34L LES has less streak artifact on CT† with good visibility during injection in comparison to OnyxTM 34 LES.4
OnyxTM 34L LES in 10 mm vessel‡
OnyxTM 34 LES in 10 mm vessel‡
Model specifications
OnyxTM Liquid Embolic System
| Product code |
Onyx formulation |
|---|---|
| 105-7200-060 |
Onyx 18 peripheral kit, 1.5 mL |
| 105-7200-080 |
Onyx 34 peripheral kit, 1.5 mL |
| 105-7315-080 |
Onyx 34L kit, 1.5 mL |
| 105-7360-080 |
Onyx 34L kit, 6 mL |
OnyxTM LES accessories
| Product code |
Onyx LES accessory |
|---|---|
| 103-1205-001 |
Vortex-Genie®* 2 120 v/60 Hz with 1.5 mL vial attachment |
| 103-1205-002 |
Vortex-Genie 2 240 v/50 Hz with 1.5 mL |
| 103-1205-100 |
Mixer attachment for 6 mL and 1.5 mL |
| 103-1207 |
Syringe catheter interface adapter |
| 103-1203 |
1 mL luer-lock injector syringe |
Manuals and technical guides
The technical manual includes indications, warnings, precautions, MRI information, and directions for use. Find it in the product labeling supplied with each device.
Request more information
This material is for Healthcare Professionals in countries with applicable health authority product registrations.
Important: Always refer to the Instructions For Use (IFU) packaged with the product/e-IFU for complete instructions, indications, contraindications, warnings, and precautions.
*
™Third-party brands are trademarks of their respective owners.
†
CT artifact validation in vitro using a water phantom tank to simulate body tissue and synthetic vessel. Document TR_NV 11300 RevA.
‡
Images are property of Medtronic.
References
1
Urbano J, Manuel Cabrera J, Franco A, Alonso-Burgos A. Selective arterial embolization with ethylene-vinyl alcohol copolymer for control of massive lower gastrointestinal bleeding: feasibility and initial experience. J Vasc Interv Radiol. June 2014;25(6):839-846.
2
Yamada R, Uflacker A, Bourgeois A, Adams JD, Guimaraes M. Embolization Therapy: Principles and Clinical Applications. Philadelphia, PA: Wolters Kluwer; 2015:582.
3
Joseph S, Chadaga HC, Murali K. Endovascular Treatment of Cerebral AVM with Onyx - Initial Experience. Interv Neuroradiol. October 5, 2005;11(Suppl 1):171-178.
4
IFU 70721-001 Rev 01/13. 2 CT artifact validation in vitro using a water phantom tank to simulate body tissue and synthetic vessel. Document TR_NV 11300 Rev A 2013-08-20. All images property of Medtronic.