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Renal denervation for hypertension

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Sign up to learn more about the Symplicity™ blood pressure procedure, whether your top priority is clinical data, procedural training, ongoing education, or gaining access to new materials for your practice.

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Take action on hypertension by building a dedicated program.

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Hypertension (HTN) remains an urgent global health challenge. Do you know how many patients remain uncontrolled with current treatments?

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Find the right patients

Explore resources for identifying patients who could benefit from the Symplicity blood pressure procedure.

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Multiple randomized controlled trials

The Symplicity blood pressure procedure has demonstrated significant and safe blood pressure reductions in two pivotal, sham-controlled trials and a real-world registry with sustained blood pressure reductions through three years.^1–3

See our trials

Böhm M, Kario K, Kandzari DE, et al. Efficacy of catheter-based renal denervation in the absence of antihypertensive medications (SPYRAL HTN-OFF MED Pivotal): a multicentre, randomised, sham-controlled trial. The Lancet 2020;395:1444–14510.

Kandzari DE, Böhm M, Mahfoud F, et al. Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial. The Lancet. 2018;391(10137):2346-2355.

Mahfoud F, Mancia G, Schmieder R, et al. Three-year safety and efficacy in the Global Symplicity Registry: Impact of antihypertensive medication burden on blood pressure reduction. Presented at PCR e-course 2020.