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Why parathyroid tissue detection?     Hypoparathyroidism challenges     KOL Voices

 

Protect with confidence1 your patient's healthy parathyroid tissue — and their quality of life2


Hypoparathyroidism after neck surgery is common3

 

Up to
22%

 

of thyroid surgeries result in incendental parathyroid removal4

 

Up to
15%

 

of total thyroidectomies result in permanent hypoparathyroidism5

 

Up to
85%

 

of permanent hypoparathyroidism results from neck surgeries5


This puts patients as risk for hypoparathyroidism — a condition associated with a number of short- and long-term complications.2,6-10

Renal


3.1x greater risk of
renal insufficienty7

Kidney


4x greater risk of
nephrolithiasis7

Brain


Neurocognitive
symptoms2,6,8

Cardiac


Cardiac
complications9,10


The burden of hypoparathyroidism is high.

Graphic


 

Hypoparathyroidism after total thyroidectomy

  1. Increases the incidence of temporary hypocalcemia to 40%11

  2. Hypocalcemia is a common reason for hospital readission12

  3. Incidental parathyroid removal increases the incidence of permanent hypocalcemia to 5.8%11

Patients with hypoparathyroidism often require emergency care 41%.13

Impact on the quality of life2


In a study with a sample size of n= 397 patients.

Patients with permanent, post-surgical hypoparathyroidism may experience increased mortality after total thyroidectomy.3

Ready to change the numbers?

Up to 96% accuracy with Medtronic PTeye™ parathyroid detection system in confirming parathyroid tissue already visually located -providing greater surgeon confidence.14


Real-time confirmation: Up to 96% accuracy in confirming the parathyroid gland¹⁴

When identified with medium confidence, PTeye™ was highly beneficial for further improving the surgeon's confidence in:


Confirming parathyroid gland tissue in 88.9% (24/27) of the cases 1


Preventing surgeon error in 7.4% of times (2/27) where the surgeon misidentified non‐parathyroid tissue as parathyroid gland tissue1

Download infographic

One-pager infographic about how surgical hypoparathyroidism impacts your patient's health and quality of life.

Download infographic

Discover the PTeye™ system

The PTeye™ parathyroid detection system is an intra-operative probe-based technology to aid you in confirming suspected parathyroid tissue during thyroid and parathyroid surgery.14

Discover PTeye™
PTeye parathyroid detection system

Get in contact and discover the PTeye™ parathyroid detection system

Learn more about the PTeye™ system live with your Medtronic representative during a product demonstration. By submitting the form, we will get a notification to reach out to you. We are looking forward to introducing this new technology to you.

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1

Kiernan CM, Thomas G, Baregamian N, Solόrzano CC. Initial clinical experiences using theintraoperative probe-based parathyroid autofluorescence identification system—PTeye™during thyroid and parathyroid procedures. J Surg Oncol. 2021;124:271–281.

2

Siggelkow H, Clarke BL, Germak J, et al. Burden of illness in not adequately controlled chronic hypoparathyroidism: Findings from a 13-country patient and caregiver survey. ClinEndocrinol (Oxf). 2020 Feb;92(2):159–168. doi: 10.1111/cen.14128. Epub 2019 Dec 11. PMID:31721256; PMCID: PMC7027891.

3

Almquist M, Ivarsson K, Nordenström E, et al. Mortality in patients with permanenthy poparathyroidism after total thyroidectomy. Br J Surg. 2018 Sep;105(10):1313–1318. doi:10.1002/bjs.10843. Epub 2018 Apr 17. PMID: 29663312.

4

Applewhite M. et al Incidence, Risk Factors, and Clinical Outcomes of Incidental Parathyroidectomy During Thyroid Surgery, Ann Surg Oncol 2016 Dec; 23(13):4310–4315. doi: 10.1245/s10434-016-5439-1. Epub 2016 Aug 19. PMID: 27541813.

5

Sitges Serra et al Etiology and Diagnosis of Permanent Hypoparathyroidism after Total Thyroidectomy. J Clin Med 2021 Feb; Pg.4; 10(3): 543. doi:10.3390/jcm10030543

6

Büttner M, Singer S, Taylor K. Quality of life in patients with hypoparathyroidism receivingstandard treatment: an updated systematic review. Endocrine. 2024 Apr 5. doi:10.1007/s12020-024-03807-2. Epub ahead of print. PMID: 38578400.

7

Underbjerg L, Sikjaer T, Mosekilde L, Rejnmark L. Cardiovascular and renal complications to postsurgical hypoparathyroidism: a Danish nationwide controlled historic follow-up study. JBone Miner Res. 2013 Nov;28(11):2277–85. doi: 10.1002/jbmr.1979. PMID: 23661265.

8

Underbjerg L, Sikjaer T, Mosekilde L, Rejnmark L. Postsurgical hypoparathyroidism-risk offractures, psychiatric diseases, cancer, cataract, and infections. J Bone Miner Res. 2014 Nov;29(11):2504–10. doi: 10.1002/jbmr.2273. PMID: 24806578.

9

Underbjerg L, Sikjaer T, Rejnmark L. Long-Term Complications in Patients WithHypoparathyroidism Evaluated by Biochemical Findings: A Case-Control Study. J Bone MinerRes. 2018 May;33(5):822–831. doi: 10.1002/jbmr.3368. Epub 2018 Feb 14. PMID: 29281760.

10

Gosmanova EO, Chen K, Ketteler M, et al. Risk of Cardiovascular Conditions in Patients withChronic Hypoparathyroidism: A Retrospective Cohort Study. Adv Ther. 2021 Aug;38(8):4246–4257. doi: 10.1007/s12325-021-01787-7. Epub 2021 Jun 24. PMID: 34165700; PMCID: PMC8342323.

11

Bai B, Chen Z, ChenW(2018) Risk factors and outcomes of incidental parathyroidectomy in thyroidectomy: A systematic review and meta-analysis. PLoS One. 2018; 13(11): e0207088. doi: 10.1371/journal.pone.0207088. PMCID: PMC6226183 PMID: 304126393.

12

Taye A., Inabnet W., Pan S., et al. Post-thyroidectomy emergency room visits and readmissions: Assessment from the Collaborative Endocrine Surgery Quality Improvement Program (CESQIP). Am J Surg 2020 Oct;220(4):813–820. doi: 10.1016/j.amjsurg.2020.02.036. Epub 2020 Feb 19

13

Chen Ket al. A retrospective, cross-sectional physician-administered chart review of 614 patients with hypoparathyroidism. Patients were evaluated over a 1-year period. The study evaluated hypoparathyroidism-related healthcare resource utilizations, symptoms, comorbidities, and laboratory value.

14

PTeye IFU M012700C001

See the device manual for detailed information regarding the instructions for use, indications, contraindications, warnings, precautions, and potential adverse events. For further information, contact your local Medtronic representative and/or consult the Medtronic website at medtronic.de.